eNOS Activity in CAV1 Knockout Mouse Eyes
نویسندگان
چکیده
منابع مشابه
Renal baroreceptor-stimulated renin in the eNOS knockout mouse.
The role of endothelium-derived nitric oxide (NO) in renal baroreceptor stimulation of renin was tested comparing endothelial nitric oxide synthase (eNOS)-deficient mice with C57BL/6J (C57) controls. We measured blood pressure, renal blood flow (RBF), and plasma renin concentration (PRC) in Inactin-anesthetized mice. Blood pressure in eNOS knockout mice was higher than in controls (100 +/- 3 vs...
متن کاملDiabetic eNOS-knockout mice develop accelerated retinopathy.
PURPOSE Dysfunction of endothelial nitric oxide synthase (eNOS) has been implicated in the pathogenesis of diabetic vascular complications. This study was undertaken to determine the role of eNOS in the development of diabetic retinopathy (DR), by investigating the functional consequences of its deficiency in the diabetic state. METHODS Diabetes was induced in eNOS-knockout (eNOS(-/-)) and C5...
متن کاملIncreased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice.
Nitric oxide (NO) can modulate arterial stiffness by regulating both functional and structural changes in the arterial wall. Tissue transglutaminase (TG2) has been shown to contribute to increased central aortic stiffness by catalyzing the cross-linking of matrix proteins. NO S-nitrosylates and constrains TG2 to the cytosolic compartment and thereby holds its cross-linking function latent. In t...
متن کاملEndothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice.
BACKGROUND/AIMS To investigate the renal phenotype under conditions of an activated renal ET-1 system in the status of nitric oxide deficiency, we compared kidney function and morphology in wild-type, ET-1 transgenic (ET+/+), endothelial nitric oxide synthase knockout (eNOS-/-) and ET+/+eNOS-/- mice. METHODS We assessed blood pressure, parameters of renal morphology, plasma cystatin C, urinar...
متن کاملEnhanced blood pressure variability in eNOS knockout mice.
It has been shown previously that endogenous nitric oxide can buffer arterial blood pressure variability in dogs and rats. In these former studies, all isoforms of the nitric oxide synthase were blocked pharmacologically and an increased blood pressure variability was observed. Thus the question as to which isoform of the nitric oxide synthase is responsible for the blood pressure buffering eff...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2016
ISSN: 1552-5783
DOI: 10.1167/iovs.15-18841